In 2018, Mukhtar got his break as a film actor with a secondary role in the 2016 film Janaan.
In 2018, he had another secondary role in Parchi, for which he was also the cinematographer.
In 2019, Mukhtar starred in the Hum TV drama Anaa opposite to Naimal Khawar, written by Samira Fazal and directed by Shahzad Kashmiri, which marked his acting debut on television as well his first lead role.
In 2020, Mukhtar hosted the Hum Style Awards. He played the role of “Dr. Haris” in another Hum TV drama called Sabaat opposite to Sarah Khan.
In 2021, he starred in the drama serial Sinf-e-Aahan. The same year, he was cast and played the role of Aswad in drama serial Hum Kahan Ke Sachay Thay alongside Mahira Khan and Kubra Khan, written by Umera Ahmad.
Usman Mukhtar is now married,his wife is not just pretty but educated as well.Usman Mukhtar recently blessed with baby girl and they named her Seira.Usman is coming in popular drama serial Pamal and getting a lot of praise by fans.
